John Cope may refer to:

• John Cope (died 1414), MP for Northamptonshire
• John Cope (died 1558), MP for Northamptonshire
• Sir John Cope, 5th Baronet (fl. 1699), MP for Banbury
• Sir John Cope, 6th Baronet (1673–1749), British banker and politician
• Sir John Cope (British Army officer) (1690–1760), British general during the 1745 Jacobite Uprising
• John Lachlan Cope (1893–1947), biologist and surgeon with the Imperial Trans-Antarctic Expedition
• Jack Cope (1913–1991), South African writer
• John Cope, Baron Cope of Berkeley (born 1937), British politician
• John Cope, Welsh geologist; see Geology of South Wales
• A pseudonym used by surgeon Hastings Gilford (1861–1941)
• A pseudonym used by Talk Talk's frontman Mark Hollis (1955–2019)

• "Hey, Johnnie Cope, Are Ye Waking Yet?", Scottish folk song
• General Sir John Coape Sherbrooke (1764-1830), British general and Governor of British North Canada
• Jonathan Cope (disambiguation)
• Cope (surname)