Joaquina is a feminine Spanish given name. Notable people with the name include:

• Joaquina Cabrera, mother of Guatemalan president Manuel Estrada Cabrera
• Joaquina Costa (born 1967), Spanish sprint canoeist
• Joaquina Kalukango, American actor
• Joaquina Maria Mercedes Barcelo Pages (1857–1940), Spanish nun, cofounder of the Augustinian Sisters of Our Lady of Consolation
• Joaquina Téllez-Girón, Marquise of Santa Cruz, daughter of Pedro Téllez-Girón, 9th Duke of Osuna
• Joaquina Vedruna de Mas (1783–1854), Spanish nun, founder of the Carmelite Sisters of the Charity
• Joaquina (singer-songwriter) (born 2004), Venezuelan singer-songwriter

• Carlota Joaquina – Princesa do Brasil, 1995 Brazilian comedy film directed and written by Carla Camurati