Jan Hofmeyr may refer to:

• Jan Hendrik Hofmeyr (Onze Jan), (1845–1909), known as "Our Jan" (Onze Jan), journalist and South African politician, leader of the Afrikaner Bond political party of the Cape Colony
• Jan Hendrik Hofmeyr (1894–1948), Nephew of "Our Jan", Rhodes Scholar, university professor and South African politician
• Jan-Hendrik S. Hofmeyr, South African biologist and complexity theorist
• Jan Hendrik Hofmeyr de Waal [af] (1871–1937), Afrikaner lawyer and politician