James or Jim Wolf, Wolfe or DeWolf may refer to:

• James DeWolf (1764–1837), American politician, privateer, and slave trader
• James Madison DeWolf (1843–1876), U.S. Army surgeon
• James Ratchford DeWolf (1787–1855), merchant and political figure in Nova Scotia
• James Wolfe (1727–1759), British general
• James Wolffe (born 1962), Scottish lawyer
• Jim Wolf (born 1969), Major League Baseball umpire
• Jim Wolf (musician) (fl. 2010s–2020s), American singer
• Jim Wolf (American football) (1952–2003), American football player
• James A. Wolfe (born 1960), former Security Director of the U.S. Senate Select Intelligence Committee (SSCI)
• James H. Wolfe (1884–1958), a chief justice of the Utah Supreme Court