James McClure may refer to:

• James H. McClure (1939–2006), British crime author and journalist, born in South Africa
• James A. McClure (1924–2011), U.S. Senator from Idaho
• James McClure (Unionist politician) (1926–2014), Northern Ireland politician
• James Focht McClure Jr. (1931–2010), U.S. federal judge
• James McClure (table tennis) (1916–2005), American table tennis player
• James Howe McClure (1851–1909), Scottish rugby football player
• James Warren McClure (1919–2004), newspaper executive and publisher
• Jimmy McClure (fl. 1920s), soccer player in the United States

• James McLure (1951–2011), American playwright