James III may refer to:

• James III of Cyprus (1473–1474)
• James III of Majorca (c. 1315–1349)
• James III of Scotland (1451–1488)
• James III, Margrave of Baden-Hachberg (1562–1590)
• James Francis Edward Stuart (1688–1766), pretender who styled himself James III of England and Ireland, and James VIII of Scotland