James Gill may refer to:

• James Gill (artist) (born 1934), American pop-artist
• James Gill (columnist), columnist for The Advocate (Louisiana)
• James Gill (Irish cricketer) (1911–2000), Irish cricketer
• James Gill (New Zealand cricketer) (1928–2019), New Zealand cricketer
• James Gill (musician), former bassist for American hardcore band Senses Fail
• James E. Gill (1901–1980), scientist, teacher, explorer and mine developer
• James Elgin Gill (born 1987), world's most premature baby
• Jim Gill (1865–1923), American baseball player
• Jimmy Gill (1894–1964), English footballer of the 1910s, and 1920s
• James Gill (footballer, born 1903), English footballer of the 1930s