James Creighton may refer to:

• Jim Creighton (1841–1862), baseball player
• James Creighton (ice hockey) (1850–1930), Canadian ice hockey pioneer from Nova Scotia
• James Edwin Creighton (1861–1924), American philosopher
• James Forbes Creighton (1879–1944), physician and politician in Saskatchewan, Canada
• Jimmy Creighton (1905–1990), ice hockey player
• James M. Creighton (1856–1946), American architect in Arizona
• Jim Creighton (basketball) (born 1950), American basketball player