Jakšić (Serbian Cyrillic: Јакшић, pronounced [jǎkʃitɕ]) is a South Slavic surname. It may refer to:

• Jakšić noble family
• a family of the Drobnjaci clan
• Ana Jakšić (c. 1473–c. 1553), Serbian and Russian noblewoman
• Đura Jakšić (1832–1878), Serbian artist
• Đurađ Jakšić (born 1977), Serbian politician
• Emilija Jakšić (1924–1949), Serbian communist
• Jakov Jakšić (1774–1848), Serbian postmaster
• Jelena Jakšić (c. 1475–after 1536), despotissa of Serbia
• Jovana Jakšić (born 1993), Serbian tennis player
• Marko Jakšić, multiple people
• Mileta Jakšić (1863–1935), Serbian poet
• Milovan Jakšić (1909–1953), Serbian footballer
• Nemanja Jakšić (born 1995), Serbian footballer
• Nenad Jakšić (born 1965), Serbian footballer
• Nikola Jakšić (born 1997), Serbian water polo player
• Petar Jakšić (born 2001), Serbian water polo player
• Svetolik Jaksic (1868–1928), Serbian diplomat and journalist
• Vladimir Jakšić (1824–1899), Serbian translator, economist, statistician and meteorologist

• All pages with titles containing Jakšić
• Jakšići (disambiguation)