Isaac Wilson may refer to:

• Isaac Wilson (physician) (1757–1844) English physician to Haslar Naval Hospital and Royal family
• Isaac Wilson (American politician), United States Representative from New York
• Isaac Wilson (English politician) (1822–1899), English industrialist and Liberal Party MP from Middlesbrough
• Isaac Wilson (New Zealand politician) (1840–1901), New Zealand MP
• Isaac Wilson (American football), American football player