Isaac Guion
Born	1755 New Rochelle, New York
Died	1823 Natchez District, Mississippi

Isaac Guion (April 6, 1755 – September 7, 1823) was American military officer, settler, and cotton plantation owner. Born in New York, he served as in the American Revolutionary War and then in the regular army. After securing the Natchez District on behalf of the War Department, he settled there and ran a cotton plantation. Two of his sons became notable lawyers and public officials in Louisiana and Mississippi. Two of his sons attended the United States Military Academy at West Point, one of whom was expelled for his participation in the 1826 cadet riot, and one of whom was killed in a duel shortly after graduation.

Guion was a lieutenant in the Continental Army during the American Revolutionary War, when he was on the staff of Alexander Hamilton.^[1] He was commissioned in the regular army after the war and supervised the official transfer of the Natchez District from Spanish military control to the United States in 1797.^[2] He settled in Adams County, Mississippi and lived near Half-Way Hill, so-called because it stood near the midpoint on the road between Natchez and Second Creek.^[3] As of 1806 he owned 300 acres in Jefferson County, Mississippi.^[4] His farm produced cotton, and supported "horses, black cattle, and hogs."^[5]

When Aaron Burr was arrested at the house of Peter Bryan Bruin at Bayou Pierre for what was alleged to be the Burr conspiracy, he was held over as a guest of "Col. Benajah Osmun, a wealthy planter residing in the vicinity. He had been an officer in the New Jersey line, and intimate with Burr. In politics he was a high-strung federalist, had been a strong partisan of John Adams, and had no confidence in Mr. Jefferson. Near by Colonel Osmun, another old military friend of similar political opinions, the veteran Maj. Isaac Guion, and with these two, and other influential gentlemen, he had daily consultations. No sterner and truer patriots lived than these two veteran soldiers, and they reposed unshaken faith in the friend whom they had seen so often tested in the time that tried men's souls; Colonel Osmun lived at the place now owned by Dr. Stanton, and Major Guion resided at the foot of the Half-way Hill, and there was a rural path between the two places trellised with vines and shaded by evergreens. This was Burr's daily resort."^[6]

In 1823 Guion was a candidate for the Mississippi State Senate from Adams County, along with Adam Bingaman.^[7][8] He died in September 1823, before the election.^[9] He may have served as Surveyor and Inspector of Revenue for the port of Natchez for a time.^[10]

Guion married Sarah Lewis, the sister of Seth Lewis, who served as Chief Justice of Mississippi Territory from 1800 to 1803.^[11] According to a Mississippian writing in 1883, "Both husband and wife were endowed with remarkable talents, and highly cultivated. Their sons inherited these gifts...John I. Guion, distinguished as lawyer and legislator, was partner of Wm. L. Sharkey and S. S. Prentiss. George W. Guion, parish Judge of Concordia, removed to Lafourche and became very prominent there."^[12]

• John Isaac Guion was a Mississippi Senate Senator and Governor of Mississippi^[13]
• Frederick L. Guion graduated West Point, class of 1823 (Cullum No. 323);^[14] killed in a duel with W. W. Yerby, "a young lawyer of Woodville," in 1824^[3]
• George Guion, Louisiana state senator
• Walter B. Guion was expelled from West Point for his involvement in the Cadet Riot of 1826; became a civil engineer, died at Princeton, Mississippi, in 1845^[15]

• Claiborne, J. F. H.; Lagrone, C. M. (1880). Mississippi, as a Province, Territory and State, with Biographical Notices of Eminent Citizens. Jackson, Mississippi: Power & Barksdale. OCLC 68181845. OL 7795030W.