An interstate is a type of high-speed, limited-access highway in the United States, part of the Interstate Highway System.

Interstate may also refer to:

• Interstate 60 (2002), a metaphysical comedy/drama road film
• Interstate (album), a 1995 album by Pell Mell
• "Interstate" (song), a song from the album Tear the Signs Down (2010) by The Automatic
• Interstate '76, a vehicular-combat video game for the Microsoft Windows computer-operating system
• Interstate '82, the sequel to Interstate '76

• United States Numbered Highway System, also called the first interstate highway system in the United States
• New England Interstate Routes, one of the regional precursors of the Interstate Highway System in the United States

• Interstate (duo), an American-based musical duo
• Interstate (typeface), a humanist sans-serif typeface designed by Tobias Frere-Jones
• Interstate Aircraft, a former American company
• Interstate Bakeries Corporation
• Interstate Batteries, an American company that markets automotive batteries
• Interstate commerce, see Commerce Clause, an enumerated power listed in the United States Constitution (Article I, Section 8, Clause 3)
• Interstate compact, a pact or treaty among various states of the United States, or between states and any foreign government
• Interstate system (world-systems theory), a theory of state relationships within world-systems theory
• Interactions between two or more nations, commonly called 'international'
• Events, transactions, travel, interactions, etc. between or amongst two or more States and territories of Australia

• All pages with titles containing interstate