Ike or IKE may refer to:

• Ike (given name), a list of people and fictional characters with the given name or nickname
• Ike (surname), a list of people
• Dwight D. Eisenhower (1890–1969), Supreme Commander of the Allied forces in Europe during World War II and President of the United States
• Reverend Ike, American minister and television evangelist Frederick J. Eikerenkoetter II (1935-2009)
• Cliff Edwards (1895-1971), American singer and voice actor known as "Ukulele Ike"

• Ike (miniseries), a 1979 television miniseries about President Dwight D. Eisenhower
• Ike: Countdown to D-Day, a 2004 American television film
• Ike, a fictional moon in the game Kerbal Space Program

• Tropical Storm Ike, three tropical cyclones
• Internet Key Exchange, a network protocol used by IPsec VPNs
• IKE Group, an economic research group at Aalborg University, Denmark
• Ike, Texas, an unincorporated community in the US
• USS Dwight D. Eisenhower, US Navy aircraft carrier nickname "the Ike"
• Dwight D. Eisenhower Expressway, part of Interstate 290 and nicknamed "the Ike"
• Inuktitut (ISO 639-3 code: ike), an Inuit language of Canada
• Ikerasak Heliport (LID airport code), Greenland