Ignacio or Nacho Rodríguez may refer to:

• Ignacio Rodríguez Galván (1816–1842), Mexican romantic writer
• Ignacio Rodríguez Iturbe (1942–2022), Venezuelan hydrologist
• Ignacio Rodríguez (footballer, born 1956), Mexican footballer
• Ignacio Rodríguez (footballer, born 2004), Argentine footballer
• Ignacio Rodríguez (basketball) (born 1970), a Spanish basketball player
• Nacho Rodríguez (footballer) (born 1982), Spanish footballer
• Juan Ignacio Rodríguez (born 1992), Spanish archer
• Ignacio Rodríguez (field hockey) (born 1996), Spanish field hockey player
• Ignacio Rodríguez (programmer) (born 1999), Uruguayan programmer