Iakovos is a transliteration of the Greek name Ἰάκωβος, which in an English form is Jacob or James. Notable people with the name include:

• Archbishop Iakovos of America (1911–2005), Primate of the Greek Orthodox Archdiocese of North and South America
• Iakovos Garmatis (1928–2017), Metropolitan of Chicago under the Ecumenical Patriarchate of Constantinople
• Iakovos Kambanellis (1921–2011), Greek poet and writer
• Iakovos Kolanian (born 1960), Armenian-Greek classical guitarist
• Iakovos Milentigievits (born 1997), Greek basketball player
• Iakovos Nafpliotis (1864–1942), Archon Protopsaltis of the Holy and Great Church of Christ in Constantinople
• Iakovos Psaltis (born 1935), Greek weightlifter
• Iakovos Rizos (1849–1926), Greek painter
• Iakovos Theofilas (1861–unknown), Greek sports shooter
• Iakovos Tombazis (c. 1782–1829), Greek ship-owner and Admiral of the Greek Navy
• Iakovos Trivolis (died 1547), Greek Renaissance humanist and writer
• Iakovos "Jake" Tsakalidis (born 1979), Georgian-born Greek basketball player

• All pages with titles beginning with Iakovos
• Saint James (disambiguation)
• Agios Iakovos, a village in Cyprus