Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene , previously known as ISGF3G.[ 5] [ 6] [ 7]
Interactions IRF9 has been shown to interact with STAT2 [ 8] [ 9] STAT1 .[ 8]
References
^ a b c ENSG00000285048 GRCh38: Ensembl release 89: ENSG00000213928, ENSG00000285048 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002325 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins" . Mol Cell Biol . 12 (8): 3315–24. doi :10.1128/MCB.12.8.3315 . PMC 364572 PMID 1630447 . ^ McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics . 49 (5): 438–45. doi :10.1007/s002510050517 . PMID 10199920 . S2CID 40575791 . ^ "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa" .^ a b Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex" . Mol. Cell. Biol . 16 (12). UNITED STATES: 6957–64. doi :10.1128/mcb.16.12.6957 . ISSN 0270-7306 . PMC 231699 PMID 8943351 . ^ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3" . J. Biol. Chem . 272 (32). UNITED STATES: 20070–6. doi :10.1074/jbc.272.32.20070 ISSN 0021-9258 . PMID 9242679 .
Further reading
Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology . 42 (5–6): 325–30. doi :10.1159/000053968 . PMID 10702714 . S2CID 22135982 . Reich NC (2002). "Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation". J. Interferon Cytokine Res . 22 (1): 103–9. doi :10.1089/107999002753452719 . PMID 11846981 . Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics . 23 (1): 42–50. doi :10.1006/geno.1994.1457 . PMID 7829101 . David M, Romero G, Zhang ZY, et al. (1993). "In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase" . J. Biol. Chem . 268 (9): 6593–9. doi :10.1016/S0021-9258(18)53292-0 PMID 8454630 . Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex" . Mol. Cell. Biol . 16 (12): 6957–64. doi :10.1128/mcb.16.12.6957 . PMC 231699 PMID 8943351 . Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3" . J. Biol. Chem . 272 (32): 20070–6. doi :10.1074/jbc.272.32.20070 PMID 9242679 . Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method" . Genomics . 46 (2): 174–82. doi :10.1006/geno.1997.5044 . PMID 9417904 . Lau JF, Parisien JP, Horvath CM (2000). "Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors" . Proc. Natl. Acad. Sci. U.S.A . 97 (13): 7278–83. Bibcode :2000PNAS...97.7278L . doi :10.1073/pnas.97.13.7278 PMC 16536 PMID 10860992 . Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein" . Mol. Cell. Biol . 22 (11): 3942–57. doi :10.1128/MCB.22.11.3942-3957.2002 . PMC 133824 PMID 11997525 . Chawla-Sarkar M, Leaman DW, Jacobs BS, et al. (2002). "Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)". J. Interferon Cytokine Res . 22 (5): 603–13. doi :10.1089/10799900252982089 . PMID 12060499 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription" . Mol. Cell. Biol . 23 (2): 620–8. doi :10.1128/MCB.23.2.620-628.2003 . PMC 151539 PMID 12509459 . Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones" . DNA Res . 10 (1): 49–57. doi :10.1093/dnares/10.1.49 PMID 12693554 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res . 295 (2): 448–59. doi :10.1016/j.yexcr.2004.01.019 . PMID 15093743 . Sakamoto S, Potla R, Larner AC (2004). "Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes" . J. Biol. Chem . 279 (39): 40362–7. doi :10.1074/jbc.M406400200 PMID 15194680 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
