Hydrophobia or hydrophobe may refer to:

• Aquaphobia, a psychological fear of water
• Hydrophobe, a term used in chemistry to describe chemical "aversions" of a molecule, or part of a molecule, to water
• Rabies, historically known as hydrophobia

• Hydrophobia (video game), a 2010 game developed by Dark Energy Digital
• Hydrophobia, a Hungarian disk magazine (1996–1997)
• "Hydrophobia", the 13th track on the Risk of Rain 2 soundtrack

• List of phobias