HTX may refer to:

• Hashitoxicosis
• Heart transplantation
• Heat exchanger
• Hemitoxin
• Higher Technical Examination Programme of the Danish educational system
• Home Team Science and Technology Agency, a statutory board in the Singapore government focusing on science and technology in public security
• Homothorax
• Houston, Texas, United States
• HTX (cryptocurrency exchange)
• Middle Hittite language, an extinct language of Anatolia
• ZIC3, a protein
• HyperTransport Expansion connector, part of the HyperTransport specification