Hoff is a surname. Notable people with the surname include:

• August Bernhard Carl Hoff (1886–1971), Lutheran pastor of Koonibba Mission in South Australia
• Benjamin Hoff, American author whose works are influenced by Taoism
• Bobby Hoff, American professional poker player
• Charles Hoff (1902–1985), Norwegian athlete, coach, sports journalist, novelist and sports administrator
• Chet Hoff, American baseball pitcher
• Christian Hoff, American actor
• C. Clayton Hoff (1908–1983), American arachnologist
• Ebbe Hoff, American doctor who researched neurology, substance abuse and diving medicine
• Edwin H. Hoff (1921-2007), American politician
• Elke Hoff (born 1957), German politician (FDP)
• Gustav A. Hoff (1852–1930), American politician
• Hans Hoff (1897–1969) Austrian psychiatrist and neurologist
• William Cooper (novelist), known as Harry Hoff, English novelist
• Jeanne Hoff (1938–2023), American psychiatrist
• Karl Hoff (1838-1890), German painter
• Katie Hoff, American swimmer
• Marcian Hoff, American co-inventor of the microprocessor and Intel executive
• Max Hoff, German sprint kayaker
• Philip H. Hoff (1924–2018), American lawyer and Governor of Vermont
• Rayner Hoff, Australian sculptor
• Ron van der Hoff, Dutch Olympic archer
• Susan Dew Hoff, American physician
• Susanna Hoffs, American musician
• Syd Hoff, American children's author and cartoonist
• Thomas Hoff, 2008 Olympic volleyball gold medalist & session chair of the FOB Workshop Week.

• Hof (surname)
• von Hoff surname
• Van 't Hof, a Dutch surname
• Jacobus Henricus van 't Hoff, Dutch winner of the first Nobel Prize in chemistry