Heem or variant thereof, may refer to:

• Jan Heem (late 13th century - early 14th century), Flemish politician
• David Davidsz de Heem (1570–1632), Dutch painter
• Jan Davidsz. de Heem (1606–1684), Dutch painter, son of David Davidsz
• Jan Janszoon de Heem (1650–1695), Dutch painter, son of Jan Davidszoon
• Cornelis de Heem (1631–1695), Dutch painter, son of Jan Davidszoon
• David Cornelisz de Heem (1663–1701), Dutch painter, son of Cornelis
• Bryce Heem (born 1989), New Zealand rugby union footballer

• Embaba Airport (ICAO airport code: HEEM), a closed airport in Giza, Egypt
• -heem (-hiem), the Frisian place-suffix, see Artificial dwelling hill

• Higher Education European Masters (HEEM), an Erasmus Mundus program

• Heme or Haem, the blood cofactor
• Himanshu Kumar Suri or Heems (born 1985), American rapper