A headache is an unpleasant sensation in the head.

Headache may also refer to:

• Headache (game), a board game
• Headache (EP), an extended-play music recording by Big Black
• Headache, a single album by Moon Jong-up
• Headache (journal), a medical journal
• "Headache" (song), a 1994 song by Frank Black
• HeadAche, a punk rock band from Hertfordshire, England
• "Headache" (Grimm), a 2015 episode of the television series Grimm