Gwendolyn is a feminine given name, a variant spelling of Gwendolen^[2] (perhaps influenced by names such as Carolyn, Evelyn and Marilyn). This has been the most popular spelling in the United States.

• Gwendolyn B. Bennett (1902–1981), American writer
• Gwendolyn Black (1911–2005), Canadian musician, educator and activist
• Gwendolyn Bradley, American soprano
• Gwendolyn T. Britt (1941–2008), American Democratic politician
• Gwendolyn Brooks (1917–2000), American poet
• Gwendoline Christie, British actress
• Gwendolyn J. Elliott (1945–2007), American police officer and founder of Gwen's Girls
• Gwendolyn Faison, American Democratic politician
• Gwendolyn A. Foster, American military officer, nurse practitioner, midwife
• Gwendolyn Audrey Foster, American professor of English and film studies
• Gwendolyn Garcia (born 1955), Filipino politician
• Gwendolyn Graham (born 1963), American serial killer
• Gwendolyn Holbrow (born 1957), American artist
• Gwendolyn L. "Gwen" Ifill (1955–2016), American journalist
• Gwendolyn King, American businesswoman
• Gwendolyn Knight (1914–2005), American sculptor
• Gwendolyn Lau, American voice actress
• Gwendolyn Lycett, British figure skater
• Gwendolyn MacEwen (1941–1987), Canadian novelist and poet
• Gwendolyn Masin (born 1977), Dutch-born violinist
• Gwendolyn O’Neal (born 1946), American academic administrator and home economist
• Gwendolyn Osborne (born 1978), British model and actress
• Gwendolyn Rutten, Belgian politician
• Gwendolyn Sanford, American singer-songwriter
• Gwendolyn Zepeda (born 1971), American author

• Gwen Cooper, a fictional character in the BBC science-fiction television programme Torchwood
• Gwendolyn "Winnie" Cooper, a central character in the American television series The Wonder Years (1988–1993)
• Haley Gwendolyn Dunphy, a main character in Modern Family
• Dark Sun Gwyndolin is a character in the 2011 video game Dark Souls
• Gwendolyn Jones, German name of Bronwyn Jones, a supporting character in the animated series Fireman Sam
• Gwendoline Lacey, a character in Enid Bylton's Malory Towers
• Gwendolyn Lancaster, main character in Jim Butcher’s The Aeronaut's Windlass first book of the Cinder Spires series
• Gwendolyn Pierce, a character in the American sitcom television series Charles in Charge
• Gwendolyn "Gwen" Poole, the title character of the comic book series Unbelievable Gwenpool.
• Gwendolyn Shepherd, main character in Kerstin Gier's Ruby Red and sequels novels.
• Gwendolyne Maxine "Gwen" Stacy, a supporting character in the Spider-Man comic book series
• Gwendolyn "Gwen" Tennyson, the cousin of Ben Tennyson on the Cartoon Network's media franchise Ben 10.
• Gwendolyn "Gwen" Winthrop, a witch in the American soap opera Passions (1999–2008)
• Gwendolyn, one of the family's pursuers in Saga comic book series
• Gwendolyn, a were-wyrm in the DLC "Desolation of Mordor" of Middle-earth: Shadow of War (2017)
• Gwendolyn, a valkyrie, one of the protagonists in the video game Odin Sphere (2007)
• Gwendolyn, a Roman centurion, a minor character in Rick Riordan's 2011 fantasy novel The Son of Neptune.
• "Gwen" (Guinevere), a main character in the television series Merlin.
• Gwendolyn Clawthorne, a minor character in The Owl House.

• Gwen (given name)
• Gwendolen
• Gwendoline