Guillermo Rodríguez may refer to:

• Guillermo Rodríguez (baseball), Venezuelan baseball catcher
• Guillermo Rodríguez (footballer), Uruguayan footballer
• Guillermo Rodríguez (athlete), Mexican Olympic sprinter
• Guillermo Rodríguez (politician), also known as Guillermo Rodríguez Lara, Ecuadorian politician
• Guillermo Rodríguez González, Spanish archer
• Guillermo Rodriguez (comedian), Recurring cast member of Jimmy Kimmel Live!