Grigoris Papazacharias (Greek: Γρηγόρης Παπαζαχαρίας; born 20 March 1985) is a Greek former footballer. He has represented Greece at all youth levels.

Papazacharias began his career in Anagennisi Epanomi. He joined Iraklis in 1999. He stayed in Iraklis for 11 years, until 2010. He has over 118 performances with blue-white jersey and he scored 6 league goals. In 2003-2004-2005 years, Iraklis was in very good form, finishing 4th behind Olympiacos, Panathinaikos and AEK Athens, with Papazaharias being in first eleven in center-back duo, with Tasos Katsabis. He was appointed as the captain for Iraklis in 2007. He was in a special love with the team's fans and was bringing very good performances. In 2010 summer, he transferred to rivals Aris, with many dreams. But he was very unlucky, because an injury left him out for about 4 months. In first season in Kleanthis Vikelidis, he played in only 3 matches (against Atromitos, AEL and Kerkyra). In 2011–2012 season, he played first in the match against Xanthi, in Kleanthis Vikelidis, with score 0–0.

On 30 June 2019, Thyella Kamari F.C. announced that they had signed Papazaharias.^[1]

• Grigoris Papazacharias at Soccerway