Galena is a mineral and an important lead ore.

Galena may also refer to:

• Galena Bay, British Columbia, a ferry terminal, community and bay
• Galena Island, an uninhabited island in Nunavut
• Galena Pass, a low mountain pass on BC 31 near Galena Bay

• Galena, Alaska, a city
• Galena, Idaho, a former mining town
• Galena, Illinois, a city and county seat
  • Galena Historic District
• Galena, Indiana, a census-designated place
• Galena, Kansas, a city
• Galena, Maryland, a town
• Galena, Missouri, a city
• Galena, Lander County, Nevada, a ghost town
• Galena, Washoe County, Nevada, a town abandoned after 1867
• Galena, Ohio, a village
• Galena, Oregon, a ghost town
• Galena, South Dakota, an unincorporated community
• Galena, Washington, an unincorporated community
• Galena Peak, a mountain in Colorado
• Galena Peak (Idaho), a mountain in Idaho
• Galena River (Illinois)
• Galena River (Indiana)
• Galena Summit, a high mountain pass in central Idaho
• Galena Township (disambiguation)
• Lake Galena (Illinois), a reservoir
• Lake Galena (Pennsylvania), a reservoir

• Galena Biopharma, American pharmaceutical company
• Galena Hotel, originally known as the Fox River House, historic hotel in Aurora, Illinois
• Galena Lodge, cross-country skiing resort in Idaho
• Ivax Pharmaceuticals, a company previously known as "Galena"

• Galena (singer), Bulgarian pop folk singer
• Ayelet Galena (2009–2012), child born with the rare genetic disorder dyskeratosis congenita

• Galena Group, a sedimentary sequence of Ordovician limestone that was deposited atop the Decorah Shale
• Galena High School (disambiguation)
• Galena Nuclear Power Plant, proposed nuclear power plant in Galena, Alaska
• USS Galena, three U.S. Navy ships
• Galena, a cultivar of hops
• Galena class, a U.S. Navy class of 19th century sloops of war

• Galena River (disambiguation)
• Galene (disambiguation)
• Galina (disambiguation)
• Garena, video game developer