GUCA1B

GUCA1B
Identifiers
Aliases	GUCA1B, GCAP2, GUCA2, RP48, guanylate cyclase activator 1B, GCAP 2
External IDs	OMIM: 602275; MGI: 1194489; HomoloGene: 1586; GeneCards: GUCA1B; OMA:GUCA1B - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	42,194,956 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,703,892 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	2979
	107477
	ENSG00000112599
	ENSMUSG00000023979
	Q9UMX6
	Q8VBV8
	NM_002098
	NM_146079
	NP_002089
	NP_666191
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.^[5]^[6] Alternative names:^[7]

Guanylate cyclase activator 1B
Retinal guanylyl cyclase activator protein p24

Biological Role

Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation.^[8] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase.^[8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112599 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023979 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, et al. (February 1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi:10.1006/geno.1996.4513. PMID 9119368.
^ "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".
^ "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.
^ ^a ^b Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K (April 1994). "Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 4014–8. Bibcode:1994PNAS...91.4014G. doi:10.1073/pnas.91.9.4014. PMC 43713. PMID 7909609.

Wiegand RC, Kato J, Huang MD, Fok KF, Kachur JF, Currie MG (October 1992). "Human guanylin: cDNA isolation, structure, and activity". FEBS Letters. 311 (2): 150–4. doi:10.1016/0014-5793(92)81387-2. PMID 1327879. S2CID 39983596.
de Sauvage FJ, Keshav S, Kuang WJ, Gillett N, Henzel W, Goeddel DV (October 1992). "Precursor structure, expression, and tissue distribution of human guanylin". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9089–93. Bibcode:1992PNAS...89.9089D. doi:10.1073/pnas.89.19.9089. PMC 50070. PMID 1409606.
Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, et al. (April 1997). "Localization of guanylate cyclase-activating protein 2 in mammalian retinas". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4727–32. Bibcode:1997PNAS...94.4727O. doi:10.1073/pnas.94.9.4727. PMC 20792. PMID 9114059.
Laura RP, Hurley JB (August 1998). "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry. 37 (32): 11264–71. doi:10.1021/bi9809674. PMID 9698373.
Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K (February 1999). "Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1". Biochemistry. 38 (5): 1387–93. doi:10.1021/bi982512k. PMID 9931003.
Payne AM, Downes SM, Bessant DA, Plant C, Moore T, Bird AC, Bhattacharya SS (September 1999). "Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies". Journal of Medical Genetics. 36 (9): 691–3. doi:10.1136/jmg.36.9.691. PMC 1734430. PMID 10507726.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, et al. (June 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision. 8: 196–204. PMID 12107411.
Sato M, Nakazawa M, Usui T, Tanimoto N, Abe H, Ohguro H (March 2005). "Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies". Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. 243 (3): 235–42. doi:10.1007/s00417-004-1015-7. PMID 15452722. S2CID 23347858.

External links

GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112599 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023979 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119368-5] Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, et al. (February 1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi:10.1006/geno.1996.4513. PMID 9119368.

[entrez-6] "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".

[7] "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.

[Gorczyca_1994-8] Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K (April 1994). "Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 4014–8. Bibcode:1994PNAS...91.4014G. doi:10.1073/pnas.91.9.4014. PMC 43713. PMID 7909609.

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Fahrer / Team für die Suche eingeben:

Fahrer / Team für die Suche eingeben:

Langbahn Team – Weltmeisterschaft

GUCA1B

Biological Role

References

Further reading

External links