G protein-coupled receptor 128 is a protein encoded by the ADGRG7gene.[5][6][7] GPR128 is a member of the adhesion GPCR family.[8][9]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]
Tissue distribution
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[11]
Function
Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[12]
Clinical significance
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[13] Notably, the fused gene was also detected in few healthy individuals.
^Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID23695165. S2CID6958640.
