Frank Burns may refer to:

• Frank Burns (Pennsylvania politician) (born 1975), Pennsylvania politician
• Frank Burns (Delaware politician), Delaware state representative
• Frank L. Burns (1939–2003), director of the US Army's Delta Force leadership project
• Frank R. Burns (1928–2012), head football coach at Johns Hopkins University and Rutgers University
• Alan Burns (rugby league) (born 1961), also known as Frank, Australian rugby league player
• Frank Burns (M*A*S*H), a character on the television show M*A*S*H

• Arthur Frank Burns, chairman of the Federal Reserve
• Frank Byrne (disambiguation)
• Francis Byrne (disambiguation)
• Francis Burns (disambiguation)