Francis Willis may refer to:

• Francis Willis (academic) (died 1597), English academic administrator at the University of Oxford and Dean of Worcester
• Francis Willis (physician) (1718–1807), British physician and clergyman, known for his treatment of George III
• Francis Willis (politician) (1745–1829), United States representative from Georgia

• Frank Willis (disambiguation)
• Frances E. Willis (1899–1983), third woman to enter the U.S. Foreign Service