Francis Smith may refer to:

• Francis Smith (by 1516-1605), member of parliament (MP) for Truro and Stafford
• Francis Smith, 2nd Viscount Carrington (c. 1621 – 1701), English peer
• Francis Ormand Jonathan Smith (1806–1876), US representative from Maine
• Francis Smith (Australian politician) (1819–1909), premier of Tasmania
• Frank Smith (British politician) (1854–1940), MP for Nuneaton, 1929–1931
• Francis Henry Smith (1868–1936), Reform Party member of parliament in New Zealand
• Francis Smith (Missouri politician) (1905–1984), American politician from Missouri
• Francis R. Smith (1911–1982), U.S. representative from Pennsylvania

• Francis Smith (British Army officer) (1723–1791), British officer during the American Revolutionary War
• Francis Henney Smith (1812–1890), first superintendent of the Virginia Military Institute
• Francis Smith (RAAF officer) (1896–1961), Australian World War I flying ace
• F. Neale Smith (1930–2020), rear admiral in the United States Navy

• Francis Pettit Smith (1808–1874), British inventor of the screw propeller
• Francis Shubael Smith (1819–1887), American publisher
• Francis Marion Smith (1846–1931), American borax magnate

• Frank Smith (rugby union) (Francis Bede Smith; 1886–1954), Australian rugby union player
• Fran Smith Jr. (born 1952), bass guitarist for The Hooters
• Francie Larrieu Smith (born 1952), American track and field athlete

• Francis Graham-Smith (born 1923), British astronomer
• Francis Hopkinson Smith (1838–1915), American author, artist and engineer
• Francis P. Smith (Duquesne University) (1907–1990), American Catholic priest and university president
• Francis Smith of Warwick (1672–1738), English architect
• Francis Smith (explorer), captain of an exploration vessel, during the Northwest Passage expedition of 1746

• Francis Wilford-Smith (1927–2009), British cartoonist, graphic artist, and producer and archivist of blues music
• Francis Smith (priest) (fl. 1917–1959), South African Anglican priest
• Francis Palmer Smith (1886–1971), American architect based in Atlanta, Georgia, also known as Francis P. Smith
• Francis Smith (judge) (1847–1912), Sierra Leonean judge in the Gold Coast
• Francis Jagoe Smith (1873–1969), Postmaster General of Ceylon

• Frank Smith (disambiguation)
• Frances Smith (disambiguation)