Francesco Quaini (1611–1680) was an Italian painter of the Baroque period.

Born in Bologna, he started as a pupil of the renowned quadratura master, Agostino Mitelli. Working together with Marcantonio Franceschini, In Bologna, Francesco painted in several public buildings, including the decoration of the Sala Farnese in the Palazzo Publico. He died at Bologna. His son Luigi Quaini also painted quadratura. Marcantonio Chiarini was one of his pupils.

• Farquhar, Maria (1855). Ralph Nicholson Wornum (ed.). Biographical catalogue of the principal Italian painters. London: Woodfall & Kinder. p. 137.
• Bryan, Michael (1889). Walter Armstrong; Robert Edmund Graves (eds.). Dictionary of Painters and Engravers, Biographical and Critical. Vol. II L-Z. London: George Bell and Sons. pp. 331–332.