Folate receptor beta is a protein that in humans is encoded by the FOLR2gene.[5][6][7]
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[7]
^van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet. 69 (3–4): 127–58. doi:10.1159/000133953. PMID7698003.
Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13". Genomics. 14 (2): 423–30. doi:10.1016/S0888-7543(05)80236-8. PMID1330883.
Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul. 29: 13–26. doi:10.1016/0065-2571(89)90091-5. PMID2561247.
Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA". Biochemistry. 28 (20): 8249–54. doi:10.1021/bi00446a042. PMID2605182.
Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID7578066.
Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity". Biochemistry. 33 (5): 1209–15. doi:10.1021/bi00171a021. PMID8110752.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Wang J, Shen F, Yan W, et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion". Biochemistry. 36 (47): 14583–92. doi:10.1021/bi970845w. PMID9398177.