Flotillin-2 is a protein that in humans is encoded by the FLOT2gene.[5][6]
Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts". Blood. 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID11159550.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID12107410.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID14667819.
Bracho C, Dunia I, Romano M, et al. (2006). "Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax". Parasitol. Res. 99 (2): 153–9. doi:10.1007/s00436-006-0139-6. PMID16521037. S2CID1099026.
Doherty SD, Prieto VG, George S, et al. (2007). "High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma". Melanoma Res. 16 (5): 461–3. doi:10.1097/01.cmr.0000222592.75858.20. PMID17013097. S2CID9758718.
Sugawara Y, Nishii H, Takahashi T, et al. (2007). "The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase". Cell. Signal. 19 (6): 1301–8. doi:10.1016/j.cellsig.2007.01.012. PMID17307333.
Song J, Chen W, Lu Z, et al. (2011). "Soluble expression, purification, and characterization of recombinant human flotillin-2 (reggie-1) in Escherichia coli". Mol Biol Rep. 38 (3): 2091–8. doi:10.1007/s11033-010-0335-4. PMID20857209. S2CID26736046.
PDB gallery
1win: Solution Structure of the Band 7 Domain of the mouse Flotillin 2 Protein