Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5gene.[5][6]
Function
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[6]
The phytocannabinoids (THC and CBD) inhibit endocannabinoidanandamide (AEA) uptake by targeting FABP5, and competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids.[7] Results show that cannabinoids inhibit keratinocyteproliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Madsen P, Rasmussen HH, Leffers H, Honoré B, Celis JE (September 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". The Journal of Investigative Dermatology. 99 (3): 299–305. doi:10.1111/1523-1747.ep12616641. PMID1512466.
^Hagens G, Roulin K, Hotz R, Saurat JH, Hellman U, Siegenthaler G (February 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Molecular and Cellular Biochemistry. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. PMID10331666. S2CID24171894.
Further reading
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID1286667. S2CID41855774.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Siegenthaler G, Hotz R, Chatellard-Gruaz D, Jaconi S, Saurat JH (January 1993). "Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP)". Biochemical and Biophysical Research Communications. 190 (2): 482–7. doi:10.1006/bbrc.1993.1073. PMID8427590.
Masouyé I, Saurat JH, Siegenthaler G (1996). "Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study". Dermatology. 192 (3): 208–13. doi:10.1159/000246367. PMID8726632.
Masouyé I, Hagens G, Van Kuppevelt TH, Madsen P, Saurat JH, Veerkamp JH, Pepper MS, Siegenthaler G (September 1997). "Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein". Circulation Research. 81 (3): 297–303. doi:10.1161/01.res.81.3.297. hdl:2066/25768. PMID9285630. S2CID21737640.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Watanabe R, Fujii H, Yamamoto A, Hashimoto T, Kameda K, Ito M, Ono T (November 1997). "Immunohistochemical distribution of cutaneous fatty acid-binding protein in human skin". Journal of Dermatological Science. 16 (1): 17–22. doi:10.1016/S0923-1811(97)00615-4. PMID9438903.
Hagens G, Roulin K, Hotz R, Saurat JH, Hellman U, Siegenthaler G (February 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Molecular and Cellular Biochemistry. 192 (1–2): 123–8. doi:10.1023/A:1006894909694. PMID10331666. S2CID24171894.
Hohoff C, Börchers T, Rüstow B, Spener F, van Tilbeurgh H (September 1999). "Expression, purification, and crystal structure determination of recombinant human epidermal-type fatty acid binding protein". Biochemistry. 38 (38): 12229–39. doi:10.1021/bi990305u. PMID10493790.
O'Shaughnessy RF, Seery JP, Celis JE, Frischauf A, Watt FM (December 2000). "PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation". FEBS Letters. 486 (2): 149–54. Bibcode:2000FEBSL.486..149O. doi:10.1016/S0014-5793(00)02252-3. PMID11113456. S2CID23327194.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID12665801. S2CID23783563.
Ha MK, Chung KY, Lee JH, Bang D, Park YK, Lee KH (September 2004). "Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells". Experimental Dermatology. 13 (9): 543–50. doi:10.1111/j.0906-6705.2004.00196.x. PMID15335354. S2CID22923459.
PDB gallery
1b56: HUMAN RECOMBINANT EPIDERMAL FATTY ACID BINDING PROTEIN
1jjj: SOLUTION STRUCTURE OF RECOMBINANT HUMAN EPIDERMAL-TYPE FATTY ACID BINDING PROTEIN
