Empress Guo may refer to:

• Guo Shengtong (6–52), wife of Emperor Guangwu of Han
• Guo Nüwang (184–235), wife of Emperor Wen of Cao Wei
• Empress Guo (Cao Rui's wife) (died 264), wife of Emperor Ming of Cao Wei
• Empress Dowager Guo (Tang dynasty) (died 848), wife of Emperor Xianzong of Tang
• Empress Guo (Zhenzong) (975–1007), wife of Emperor Zhenzong of Song
• Empress Guo (Renzong) (1012–1035), wife of Emperor Renzong of Song
• Empress Xiaoyuanzhen (1580–1613), wife of the Taichang Emperor