Efren or Efrén is a given name. Notable people with the name include:

• Efrén Echeverría (born 1932), musician guitarist, composer, and compiler from Paraguay
• Efrén Pérez Rivera (born 1929), former college professor and noted Puerto Rican environmentalist leader
• Efrén Rebolledo (1877–1929), Mexican poet and diplomat
• Efrén Vázquez (born 1986), Spanish Grand Prix motorcycle road racer in the 250 cc World Championship riding a Derbi
• Efren de la Cruz (born 1989), Ecuadorian footballer who plays for LDU Quito
• Efren Herrera (born 1951), former American football place-kicker and wide receiver in the National Football League
• Efren Peñaflorida (born 1981), teacher and social worker in the Philippines
• Efren Ramirez (born 1973), American actor
• Efren Reyes (born 1954), Filipino professional pool player from Angeles City and a two-time world champion
• Efren Reyes Jr. (born 1962), Filipino actor
• Efren Saldivar (born 1969), American serial killer who murdered patients while working as a respiratory therapist
• Efren Torres (born 1943), former a Mexican boxer, who was world champion in the Flyweight division

• Sa Paraiso ni Efren (English: Efren's Paradise), a film that tackles interwoven four-way emotional entanglements