Edward, Ed, Ned, or Ted Murphy may refer to:

• Edward F. Murphy (died 1908), U.S. Army corporal, Medal of Honor recipient for actions during the Indian Wars in 1879
• Edward Murphy (Medal of Honor) (died 1924), U.S. Army private, Medal of Honor recipient for actions during the Indian Wars in 1869
• Edward R. Murphy (naval officer) (born 1937), U.S. Navy officer, executive officer of the USS Pueblo

• Edward Murphy (politician) (1818–1895), Canadian senator
• Edward Murphy Jr. (1836–1911), U.S. senator from New York, and mayor of Troy, New York
• Edward Joseph Murphy, Canadian politician
• Edward Sullivan Murphy (1880–1945), Northern Irish politician
• Edward Preston Murphy (1904–1958), U.S. federal judge

• Ned Murphy (fl. 1880s), Irish sportsman
• Ed Murphy (pitcher) (1877–1935), American baseball player for the Philadelphia Phillies
• Ed Murphy (first baseman) (1918–1991), American baseball player for the Philadelphia Phillies
• Edward Murphy (cricketer) (1921–2020), English cricketer
• Ed Murphy (soccer) (1930–2005), Scottish-born soccer player, played for the U.S. national team, 1955–1969
• Ed Murphy (basketball, born 1941), American college basketball coach
• Ted Murphy (Australian footballer) (born 1947), Australian rules footballer
• Ed Murphy (basketball, born 1956), American basketball player
• Edward Murphy (rower) (born 1971), American rower
• Ed Murphy (rugby league) (born 1992), Australian rugby league player

• Edward Murphy (bishop) (1651–1728), Irish Roman Catholic Archbishop of Dublin
• Edward Henry Murphy (c.1796–1847), Irish painter
• Edward A. Murphy Jr. (1918–1990), American aerospace engineer, namesake of "Murphy's Law"
• Edward A. Murphy (chemist) (fl. 1920s–1930s), Dunlop researcher credited with the invention of latex foam
• Ed Murphy (activist) (born 1945), American activist
• Edward H. Murphy (fl. 1970s–2000s), American businessman, executive of the American Petroleum Institute
• Edward Francis Murphy (1892–1975), American playwright, novelist, educator, and Catholic priest

• Edward Murphy Markham (1877–1950), U.S. Army general
• Eddie Murphy (disambiguation)
• Edward Murray (disambiguation)