Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene .[ 5] [ 6]
EIF5 is a GTPase-activating protein .[ 7]
References
External links Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factorsPDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)
Further reading
Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2" . J. Biol. Chem . 272 (50): 31712–8. doi :10.1074/jbc.272.50.31712 PMID 9395514 . Bandyopadhyay A, Maitra U (1999). "Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 (eIF3): demonstration that eIF3 interacts with eIF5 in mammalian cells" . Nucleic Acids Res . 27 (5): 1331–7. doi :10.1093/nar/27.5.1331 . PMC 148320 PMID 9973622 . Das S, Maitra U (2000). "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo" . Mol. Cell. Biol . 20 (11): 3942–50. doi :10.1128/MCB.20.11.3942-3950.2000 . PMC 85746 PMID 10805737 . Choi SK, Olsen DS, Roll-Mecak A, et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2" . Mol. Cell. Biol . 20 (19): 7183–91. doi :10.1128/MCB.20.19.7183-7191.2000 . PMC 86272 PMID 10982835 . Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein" . J. Biol. Chem . 276 (9): 6720–6. doi :10.1074/jbc.M008863200 PMID 11092890 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Asano K, Shalev A, Phan L, et al. (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation" . EMBO J . 20 (9): 2326–37. doi :10.1093/emboj/20.9.2326 . PMC 125443 PMID 11331597 . Majumdar R, Bandyopadhyay A, Deng H, Maitra U (2002). "Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo" . Nucleic Acids Res . 30 (5): 1154–62. doi :10.1093/nar/30.5.1154 . PMC 101238 PMID 11861906 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners" . Proc. Natl. Acad. Sci. U.S.A . 100 (4): 1535–40. Bibcode :2003PNAS..100.1535M . doi :10.1073/pnas.0437845100 PMC 149867 PMID 12569173 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Homma MK, Wada I, Suzuki T, et al. (2005). "CK2 phosphorylation of eukaryotic translation initiation factor 5 potentiates cell cycle progression" . Proc. Natl. Acad. Sci. U.S.A . 102 (43): 15688–93. Bibcode :2005PNAS..10215688H . doi :10.1073/pnas.0506791102 PMC 1266118 PMID 16227438 . Conte MR, Kelly G, Babon J, et al. (2006). "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors". Biochemistry . 45 (14): 4550–8. doi :10.1021/bi052387u . PMID 16584190 . Bieniossek C, Schütz P, Bumann M, et al. (2006). "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5". J. Mol. Biol . 360 (2): 457–65. doi :10.1016/j.jmb.2006.05.021 . PMID 16781736 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 .
