Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene .[ 5] [ 6]
Function Eukaryotic translation initiation factor 2 (eIF2 ) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α) , beta (β, this article), and gamma (γ) , with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP , which recycles the eIF2 complex for another round of initiation.[ 6]
Regulation Both eIF2α and eIF2β expression is regulated by the NRF1 transcription factor .[ 7]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000125977 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074656 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Pathak VK, Nielsen PJ, Trachsel H, Hershey JW (Sep 1988). "Structure of the beta subunit of translational initiation factor eIF-2". Cell . 54 (5): 633–9. doi :10.1016/S0092-8674(88)80007-2 . PMID 3044606 . S2CID 54414457 . ^ a b "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa" .^ Chiorini JA, Miyamoto S, Harkin SJ, Safer B (February 1999). "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter" . J. Biol. Chem . 274 (7): 4195–201. doi :10.1074/jbc.274.7.4195 PMID 9933616 .
Further reading
Welsh GI, Price NT, Bladergroen BA, et al. (1994). "Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2". Biochem. Biophys. Res. Commun . 201 (3): 1279–88. doi :10.1006/bbrc.1994.1843 . PMID 8024572 . Brand SR, Kobayashi R, Mathews MB (1997). "The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR" . J. Biol. Chem . 272 (13): 8388–95. doi :10.1074/jbc.272.13.8388 PMID 9079663 . Das S, Maiti T, Das K, Maitra U (1998). "Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2" . J. Biol. Chem . 272 (50): 31712–8. doi :10.1074/jbc.272.50.31712 PMID 9395514 . Ting NS, Kao PN, Chan DW, et al. (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45" . J. Biol. Chem . 273 (4): 2136–45. doi :10.1074/jbc.273.4.2136 PMID 9442054 . Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B" . J. Biol. Chem . 273 (5): 3039–44. doi :10.1074/jbc.273.5.3039 PMID 9446619 . Chiorini JA, Miyamoto S, Harkin SJ, Safer B (1999). "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter" . J. Biol. Chem . 274 (7): 4195–201. doi :10.1074/jbc.274.7.4195 PMID 9933616 . Cai R, Carpick B, Chun RF, et al. (2000). "HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms". Arch. Biochem. Biophys . 373 (2): 361–7. doi :10.1006/abbi.1999.1583 . PMID 10620360 . Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R (2000). "Recognition of 5′-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2" . Nucleic Acids Res . 28 (4): 1011–8. doi :10.1093/nar/28.4.1011 . PMC 102579 PMID 10648795 . Das S, Maitra U (2000). "Mutational Analysis of Mammalian Translation Initiation Factor 5 (eIF5): Role of Interaction between the β Subunit of eIF2 and eIF5 in eIF5 Function In Vitro and In Vivo" . Mol. Cell. Biol . 20 (11): 3942–50. doi :10.1128/MCB.20.11.3942-3950.2000 . PMC 85746 PMID 10805737 . Gomez E, Pavitt GD (2000). "Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation" . Mol. Cell. Biol . 20 (11): 3965–76. doi :10.1128/MCB.20.11.3965-3976.2000 . PMC 85753 PMID 10805739 . Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein" . J. Biol. Chem . 276 (9): 6720–6. doi :10.1074/jbc.M008863200 PMID 11092890 . Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA Binding Protein Nuclear Factor 90 Functions as Both a Positive and Negative Regulator of Gene Expression in Mammalian Cells" . Mol. Cell. Biol . 22 (1): 343–56. doi :10.1128/MCB.22.1.343-356.2002 . PMC 134226 PMID 11739746 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Kebache S, Zuo D, Chevet E, Larose L (2002). "Modulation of protein translation by Nck-1" . Proc. Natl. Acad. Sci. U.S.A . 99 (8): 5406–11. Bibcode :2002PNAS...99.5406K . doi :10.1073/pnas.082483399 PMC 122782 PMID 11959995 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Llorens F, Roher N, Miró FA, et al. (2004). "Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity" . Biochem. J . 375 (Pt 3): 623–31. doi :10.1042/BJ20030915 . PMC 1223719 PMID 12901717 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature . 433 (7021): 77–83. Bibcode :2005Natur.433...77A . doi :10.1038/nature03207 . PMID 15635413 . S2CID 4344740 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 .
