Down and out may refer to:

• "Down and Out" (George Strait song), 1981
• "Down and Out" (Cam'ron song), 2004
• "Down and Out" (Tantric song)
• "Down and Out," a song from the 1997 album Symbols by KMFDM
• "Down and Out" a song from the 2005 album Almost Here by The Academy Is...
• "Down and Out," a song from the 1978 album ...And Then There Were Three... by Genesis
• "Down and Out," a song from the B-side of the 1973 "Photograph" single by Ringo Starr
• Down 'n' Outz, a cover band fronted by Def Leppard's Joe Elliott

• Down and Out (film), a 1977 short film created by Aardman Animations
• Down and out (football), a passing play in American football where the quarterback passes to a pre-arranged wide receiver
• In finance, a kind of barrier option
• Down and out gaze, the direction of the eye ipsilaterally to an oculomotor nerve palsy