Domnina can refer to:

• Domnina (daughter of Nero), alleged daughter of Emperor Nero according to a Christian tradition
• St. Domnina of Terni, 3rd-century Christian martyr at Terni, Italy (feast day: April 14)
• St. Domnina of Anazarbus, 3rd-century Christian martyr at Anazarbus, Asia Minor (feast day: October 12)
• Sts. Domnina, Berenice, and Prosdoce, 4th-century martyrs (feast day: October 4)
• St. Domnina of Syria, 5th century ascetic (feast day: March 1)
• Oksana Domnina, Russian ice dancer
• Domnina (genus), an extinct shrew genus in the obsolete taxon Soricomorpha