Doe is the surname of:

• Benjamin Doe (born 1999), Liberian footballer
• Brian Doe (1862–1941), Australian politician
• Charles Doe (1898–1995), American rugby union player.
• David Doe (born 2000), Canadian soccer player
• Donald Brian Doe (1920–2005), British archaeologist and architect
• Edward M. Doe (1850-1919), American jurist
• Francis Doe (born 1985), Liberian footballer
• Fred Doe (1864–1938), American baseball pitcher
• Samuel Gbaydee Doe (born 1966), peacebuilding and conflict analyst from Liberia
• Samuel Doe (1951–1990), president of Liberia 1980–1990
• John Doe or Jane Doe, a name used as a placeholder for an unknown or anonymous person, especially in a legal context
• Joseph Doe (1855–1925), American military officer, politician and baseball player.
• Janet Doe (1895–1985), medical librarian
• Michael Doe (businessman) (died 1990), British-Liberian businessman
• Michael Doe (bishop) (born 1947), British bishop
• Nancy Doe (born 1949), First Lady of Liberia
• Nicholas B. Doe (1786–1856), American politician
• Thomas Doe (1912–1969), American bobsledder
• William Doe (1941-2022), Australian professor