Del Duca may refer to:

• Antonio del Duca (1491–1564), a Sicilian friar
• Cino Del Duca (1899–1967), an Italian-born businessman film producer and philanthropist
• Giacomo del Duca (c. 1520–1604), an Italian sculptor and architect
• Marcello Del Duca (born 1950), an Italian former water polo player
• Simone Del Duca (1912–2004), a French businesswoman, and major philanthropist, married to Cino Del Duca
• Steven Del Duca (born c. 1973), a Canadian politician and former leader of the Ontario Liberal Party

• Prix mondial Cino Del Duca, an international literary award
• Simone and Cino Del Duca Foundation, a charitable foundation based in Paris
• Stadio Cino e Lillo Del Duca, a multi-purpose stadium in Ascoli Piceno, Italy