De Bruyn is a Dutch and Afrikaans surname. "Bruyn" or "bruijn" is an archaic spelling of "bruin", meaning "brown". People with the name include:

• Aad de Bruyn (1910–1991), Dutch 35-fold national champion in discus, shot put and hammer throw
• Abraham de Bruyn (c.1539–1587), Flemish engraver
• Anna Maria de Bruyn (1708–1744), Dutch stage actress and ballet dancer
• Brian de Bruyn (b. 1954), Canadian-born Dutch ice hockey player
• Erik de Bruyn (b. 1962), Dutch film director and actor
• Ettiene de Bruyn (b. 1977), South African cricketer
• Frans De Bruyn (1924–2014), Flemish writer
• Günter de Bruyn (1926–2020), German author
• Joe de Bruyn (b. 1949), Australian trade union official
• John de Bruyn (b. 1956), Dutch-Canadian ice hockey goaltender
• Léon De Bruyn [fr; nl] (1838–1908), Belgian politician
• Michelle De Bruyn (b. 1965), New Zealand professional football player
• Nicolaes de Bruyn (1571–1656), Flemish engraver
• Paul de Bruyn (1907–1997), German-American marathon runner
• Pierre de Bruyn (b. 1977), South African cricketer
• Piet De Bruyn (b. 1968), Belgian politician
• Robert de Bruyn (b. 1991), South African rugby player
• Sophia De Bruyn (b. 1938), South African anti-apartheid activist and provincial legislator
• Theunis de Bruyn (b. 1992), South African cricketer
• Tewis de Bruyn (b. 1982), South African rugby player
• Willem de Bruyn [fr; it; nl] (1649–1719), Flemish architect
• Zander de Bruyn (b. 1975), South African cricketer
• Ray de Bruyn (b. 1963), cousin of above South African cricketer

• Cornelis Adriaan Lobry van Troostenburg de Bruyn (1857–1904), Dutch chemist
• Gerrit Willem van Oosten de Bruyn (1727–1797), Dutch lawyer
• Jacob Leonard de Bruyn Kops (1822–1887), Dutch economist and politician

• 273230 de Bruyn, an asteroid
• De Bruijn
• De Bruin
• De Bruyne