Daud Khan may refer to:

• Daud Ali Khan (died 1883), nawab of Masulipatam in India
• Daud Khan (cricketer) (1912–1979), cricket player and umpire
• Daud Khan Karrani (reigned 1572–76), Bengali ruler who fought the armies of Akbar the Great
• Daud Khan Panni, nawab of Carnatic
• Daud Khan Undiladze, 17th-century Georgian official in the Iranian service
• Daud Shah of Gujarat (born Daud Khan), 15th-century ruler of the Gujarat Sultanate in India; r. 1458–1458
• David XI of Kartli (died 1579), aka Daud Khan of Kartli, Muslim Georgian king
• Mohammed Daoud Khan (1909–1978), president of the Republic of Afghanistan