Human protein and coding gene
Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene .[ 5] [ 6]
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[ 6]
Interactions DVL2 has been shown to interact with Zinc finger protein 165 ,[ 7] DAB2 [ 8] Arrestin beta 1 .[ 9]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000004975 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020888 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome . 7 (6): 475–6. doi :10.1007/s003359900144 . PMID 8662242 . S2CID 39619679 . ^ a b "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)" .^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . ^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)" . EMBO J . 22 (12): 3084–94. doi :10.1093/emboj/cdg286 . ISSN 0261-4189 . PMC 162138 PMID 12805222 . ^ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins" . Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. Bibcode :2001PNAS...9814889C . doi :10.1073/pnas.211572798 ISSN 0027-8424 . PMC 64954 PMID 11742073 .
Further reading
Pizzuti A, Amati F, Calabrese G, et al. (1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene" . Hum. Mol. Genet . 5 (7): 953–8. doi :10.1093/hmg/5.7.953 PMID 8817329 . Klingensmith J, Yang Y, Axelrod JD, et al. (1997). "Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2" . Mech. Dev . 58 (1–2): 15–26. doi :10.1016/S0925-4773(96)00549-7 PMID 8887313 . S2CID 16004832 . Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family" . Genomics . 42 (2): 302–10. doi :10.1006/geno.1997.4713 PMID 9192851 . Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription" . J. Biol. Chem . 275 (4): 2399–403. doi :10.1074/jbc.275.4.2399 PMID 10644691 . Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells" . J. Biol. Chem . 275 (31): 23790–7. doi :10.1074/jbc.M909107199 PMID 10806215 . Zhang Y, Neo SY, Han J, Lin SC (2000). "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase" . J. Biol. Chem . 275 (32): 25008–14. doi :10.1074/jbc.M002491200 PMID 10829020 . Chen W, Hu LA, Semenov MV, et al. (2002). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins" . Proc. Natl. Acad. Sci. U.S.A . 98 (26): 14889–94. Bibcode :2001PNAS...9814889C . doi :10.1073/pnas.211572798 PMC 64954 PMID 11742073 . Habas R, Kato Y, He X (2002). "Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1" . Cell . 107 (7): 843–54. doi :10.1016/S0092-8674(01)00614-6 PMID 11779461 . S2CID 16894557 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Habas R, Dawid IB, He X (2003). "Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation" . Genes Dev . 17 (2): 295–309. doi :10.1101/gad.1022203 . PMC 195976 PMID 12533515 . Chen W, ten Berge D, Brown J, et al. (2003). "Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4". Science . 301 (5638): 1391–4. Bibcode :2003Sci...301.1391C . doi :10.1126/science.1082808 . PMID 12958364 . S2CID 34975427 . Wong CK, Luo W, Deng Y, et al. (2004). "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms" . J. Biol. Chem . 279 (38): 39366–73. doi :10.1074/jbc.M404598200 PMID 15262978 . Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family" . J. Biol. Chem . 279 (50): 52703–13. doi :10.1074/jbc.M408675200 PMID 15456783 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Zhang L, Gao X, Wen J, et al. (2006). "Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation" . J. Biol. Chem . 281 (13): 8607–12. doi :10.1074/jbc.M600274200 PMID 16446366 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 .
