Protein-coding gene in the species Homo sapiens
Denticleless protein homolog is a protein that in humans is encoded by the DTL gene .[ 5] [ 6]
Interactions DTL (gene) has been shown to interact with P21 .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000143476 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037474 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation" . J Biol Chem . 276 (20): 17083– 91. doi :10.1074/jbc.M010802200 PMID 11278750 . ^ "Entrez Gene: DTL denticleless homolog (Drosophila)" .^ Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex" . Genes Dev . 22 (18): 2496– 506. doi :10.1101/gad.1676108 . PMC 2546691 PMID 18794347 .
Further reading
Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes" . Cell Cycle . 5 (15): 1719– 29. doi :10.4161/cc.5.15.3150 PMID 16861890 . Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage" . Cell Cycle . 5 (15): 1675– 80. doi :10.4161/cc.5.15.3149 PMID 16861906 . Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1" . Mol. Cell . 23 (5): 709– 21. doi :10.1016/j.molcel.2006.08.010 PMID 16949367 . Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285– 92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nat. Cell Biol . 8 (11): 1277– 83. doi :10.1038/ncb1490 . hdl :10397/34293 PMID 17041588 . S2CID 22180568 . Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint" . Genes Dev . 20 (22): 3117– 29. doi :10.1101/gad.1482106 . PMC 1635147 PMID 17085480 . Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma" (PDF) . Cell Cycle . 5 (22): 2676– 87. doi :10.4161/cc.5.22.3500 PMID 17106265 .
