Protein-coding gene in the species Homo sapiens
ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene .[ 5] [ 6]
Function This gene encodes a member of the Asp -Glu -Ala -Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases , and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation , nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis , spermatogenesis , and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.[ 6]
Interactions DDX42 has been shown to interact with SF3B1 .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000198231 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020705 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS (Apr 2000). "Identification of a novel human member of the DEAD box protein family". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1501 (1): 63–9. doi :10.1016/S0925-4439(00)00010-7 . PMID 10727850 . ^ a b "Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42" .^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . The EMBO Journal . 21 (18): 4978–88. doi :10.1093/emboj/cdf480 . PMC 126279 PMID 12234937 .
Further reading
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Uhlmann-Schiffler H, Jalal C, Stahl H (2006). "Ddx42p--a human DEAD box protein with RNA chaperone activities" . Nucleic Acids Research . 34 (1): 10–22. doi :10.1093/nar/gkj403 . PMC 1325199 PMID 16397294 . Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain" . Molecular & Cellular Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (Sep 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . The EMBO Journal . 21 (18): 4978–88. doi :10.1093/emboj/cdf480 . PMC 126279 PMID 12234937 .
