Crosse is a surname, and may refer to:

• Andrew Crosse (1784–1855), British amateur scientist
• Charles Crosse, British rugby
• Charles G. Crosse, American physician and politician
• Edmond Francis Crosse (1858–1941), first Archdeacon of Chesterfield
• John Crosse (announcer) (born 1939), English radio DJ, presenter and continuity announcer
• John Crosse (antiquary) (1786–1833), British antiquary and music writer
• John Green Crosse (1790–1850), English surgeon
• Joseph Charles Hippolyte Crosse (1826–1898), a French conchologist
• Lavinia Crosse, founder of the Community of All Hallows religious order
• Roger Crosse, character in James Clavell's novel Noble House
• Rupert Crosse (1927–1973), American television and film actor
• Victoria Crosse, a pseudonym of novelist Annie Sophie Cory (1868–1952)

• Crosse Baronets, title in the Baronetage of Great Britain
• Lacrosse stick, sometimes known as a crosse
• Cross (surname)
• Cross (disambiguation)
• Crosses (disambiguation)