Crispin may refer to:

• Crispin (given name)
• Crispin (surname)
• Crispin and Crispinian, Christian saints
• Crispin of Pavia, Bishop of Pavia and saint
• Crispin, Bishop of Csanád
• Crispin of Viterbo (1668–1750), Italian saint and member of the Order of Friars Minor Capuchin

• SS Crispin (1907), a cargo ship built in 1907 and sunk in 1917
• HMS Crispin (1940), a cargo ship and ocean boarding vessel launched in 1934 and sunk in 1941
• HMS Crispin, a destroyer launched in 1945 and renamed PNS Jahangir in 1956

• Crispin: The Cross of Lead, a 2002 children's novel
• Crispin: At the Edge of the World, a 2006 children's novel
• Crispin: The Pig Who Had It All, a 2000 picture book by Ted Dewan

• Crispin (Shannara), a character in Terry Brooks' Shannara novels
• Crispin (wizard), a character in King's Quest V: Absence Makes the Heart Go Yonder! video game
• Crispin, a character in The Mistmantle Chronicles by M. I. McAllister
• Crispin, a supporting character from the 2003 film Daddy Day Care

• Crispin (apple) or Mutsu apple, a cross between the Golden Delicious and the Indo apple varieties
• Crispin Hard Cider Company
• Crispin School, a secondary school in Street, Somerset, England
• Crispin, the subject of Wallace Stevens' long poem "The Comedian as the Letter 'C'"
• Crispin, a trade name for tramadol

• St Crispins Hospital, a psychiatric hospital in Duston, Northamptonshire, England
• St Crispin's School, a co-educational comprehensive school in Wokingham, Berkshire, England
• Crispin rival de son maître, a one-act farce by Alain-René Lesage that was first produced in 1707
• Order of the Knights of St. Crispin, American labor union of shoeworkers
• Saint Crispin's Day, the feast day of the Christian saints Crispin and Crispinian
• St Crispin Street Fair, annual fun fair held in town centre streets of Northampton, England
• Crispian
• Crispiano, town and comune in southeast Italy